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Re: Investor2014 post# 403995

Monday, 02/20/2023 8:04:03 AM

Monday, February 20, 2023 8:04:03 AM

Post# of 458363
Remember this thread on the oncology paper by Nassim Taleb?

I do , so now we finally accept that is a non linear response curve?

Better late than never, tell that to our medical lecturer who keeps using the gaussian.

A tolerability dosage scheme should not be confused with a Convex / U-shaped or other non-linear Responses curve to a drug.

Anavex claims that there is a (largely was it not for a few outliers) linear relationship between A2-73 dose, concentration and response.



Not confused, not saying we have the same response.

Have to recycle post ran out, but my point is that we might be able to improve our response by dosage scheme, when and how often.

An on and off dosage scheme that can improve the response with INCREASED dosage for short periods.

See all foot notes in page 4 please.

https://arxiv.org/pdf/2209.14631.pdf

A tolerability dosage scheme should not be confused with a Convex / U-shaped or other non-linear Responses curve to a drug.

Anavex claims that there is a (largely was it not for a few outliers) linear relationship between A2-73 dose, concentration and response.

Page 4 is what I find very interesting.

It may help explain our distribution response to 2-73.

If my memory is not failing me at one point Dr.M did mention we were working on a specific dosage schedule, one that maximized our effect.

Moreover how the DISTRIBUTION TREATMENT produced, is not a NORMAL distribution as some "STAT" experts have uses.

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