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Sunday, February 19, 2023 5:32:43 PM
With long-lasting disease-modifying properties at low dose, AF710B [Anavex 3-71] is a promising novel therapeutic agent for treating Alzheimer's and other related diseases.
Those who haven't studied or are unaware of the several other molecules Anavex owns will focus only on blarcamesine (Anavex 2-73). But Anavex owns several other significant and promising sigma-1 receptor antagonists (activators). Right now, the most promising of these others is Anavex 3-71. All experimental evidence, in lab rodents (murines), shows that this molecule activates the sigma-1 protein at concentrations far lower than blarcamesine. In both humans and murines blarcamesine is administered in milligrams. Anavex 3-71 is dosed in micrograms. One milligram is a thousandth of gram. A microgram is a millionth of a gram.
The significance of that? First, per-dose manufacturing costs for Anavex 3-71 will be but a small fraction of those for blarcamesine. A decided economic benefit for the company. At the same time manufacturing costs can be lower but profit margins higher. Everyone will benefit.
But, of course, that will work only if Anavex 3-71 equals or exceeds blarcamesine's efficacies and safety. From the publicly-available murine studies it appears that this will be the case. Only proper clinical trials in humans will decide the matter. Very likely, as soon as Anavex has a revenue stream, human trials with Anavex 3-71 will commence.
Very likely, blarcamesine will be the first Anavex drug to get FDA approval, for any one of these debilities: Rett syndrome, Parkinson's disease dementia, and/or Alzheimer's disease. But it's very likely that blarcamesine's clinical life will be short; after successful human trials it will be replaced with Anavex 3-71.
Anavex Life Sciences Corp is not a one-trick pony (or one-molecule biotech). The activation of the sigma-1 receptor protein, by either blarcamesine or Anavex 3-71, will treat or prevent a number of central nervous system diseases.
Anavex's CNS drug firepower is broad and strong. Let's see what happens in the next five years. Not a one-trick pony. The Anavex barn has a unique molecular herd of powerful new stallion-type drugs.
Recent AVXL News
- Anavex Life Sciences to Present at the H.C. Wainwright 5th Annual Neuro Perspectives Virtual Conference • GlobeNewswire Inc. • 06/20/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/17/2024 11:30:10 AM
- Anavex Life Sciences Announces Expansion of Leadership Team • GlobeNewswire Inc. • 05/22/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/17/2024 10:01:00 AM
- Anavex Life Sciences to Present at the H.C. Wainwright 2nd BioConnect Investor Conference at NASDAQ • GlobeNewswire Inc. • 05/14/2024 11:30:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) Urged to Join Class Action - Contact The Gross Law Firm to Learn More • PR Newswire (US) • 05/10/2024 09:45:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/09/2024 08:35:55 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/09/2024 12:00:30 PM
- Anavex Life Sciences Reports Fiscal 2024 Second Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 05/09/2024 11:30:00 AM
- The Gross Law Firm Announces the Filing of a Securities Class Action on Behalf of Anavex Life Sciences Corporation(AVXL) Shareholders • PR Newswire (US) • 05/07/2024 09:45:00 AM
- Form DEFA14A - Additional definitive proxy soliciting materials and Rule 14(a)(12) material • Edgar (US Regulatory) • 05/06/2024 10:03:33 AM
- Anavex Life Sciences Corporation Sued for Securities Law Violations - Contact The Gross Law Firm Before May 13, 2024 to Discuss Your Rights - AVXL • PR Newswire (US) • 05/03/2024 09:45:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Second Quarter Financial Results on Thursday, May 9th, 2024 • GlobeNewswire Inc. • 05/02/2024 11:30:00 AM
- May 13, 2024 Deadline: Contact The Gross Law Firm to Join Class Action Suit Against AVXL • PR Newswire (US) • 04/26/2024 09:45:00 AM
- Contact The Gross Law Firm by May 13, 2024 Deadline to Join Class Action Against Anavex Life Sciences Corporation(AVXL) • PR Newswire (US) • 04/19/2024 09:45:00 AM
- The Gross Law Firm Reminds Shareholders of a Lead Plaintiff Deadline of May 13, 2024 in Anavex Life Sciences Lawsuit - AVXL • PR Newswire (US) • 04/16/2024 09:45:00 AM
- Class Action Filed Against Anavex Life Sciences Corporation (AVXL) - May 13, 2024 Deadline to Join - Contact The Gross Law Firm • PR Newswire (US) • 04/12/2024 09:45:00 AM
- Anavex Life Sciences to Present at the Noble Capital Markets Virtual Healthcare Equity Conference • GlobeNewswire Inc. • 04/11/2024 11:30:00 AM
- Class Action Filed Against Anavex Life Sciences Corporation (AVXL) - May 13, 2024 Deadline to Join - Contact The Gross Law Firm • PR Newswire (US) • 04/09/2024 09:45:00 AM
- Anavex Life Sciences Corporation Class Action: The Gross Law Firm Reminds Anavex Life Sciences Investors of the Pending Class Action Lawsuit with a Lead Plaintiff Deadline of May 13, 2024 - AVXL • PR Newswire (US) • 04/05/2024 09:45:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) should contact The Gross Law Firm about pending Class Action - AVXL • PR Newswire (US) • 04/02/2024 09:45:00 AM
- Lost Money on Anavex Life Sciences Corporation(AVXL)? Join Class Action Suit Seeking Recovery - Contact The Gross Law Firm • PR Newswire (US) • 03/29/2024 09:45:00 AM
- Investors who lost money on Anavex Life Sciences Corporation(AVXL) should contact The Gross Law Firm about pending Class Action - AVXL • PR Newswire (US) • 03/26/2024 09:45:00 AM
- Anavex Life Sciences to Present at the 23rd Annual Needham Virtual Healthcare Conference • GlobeNewswire Inc. • 03/25/2024 11:30:00 AM
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