Anavex Life Sciences Corp (AVXL): Anavex's blarcamesine and/or Anavex...

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georgejjl

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Wednesday, 02/08/2023 4:48:20 PM

Wednesday, February 08, 2023 4:48:20 PM

Anavex's blarcamesine and/or Anavex 3-71 can be used to treat and/or prevent cardiovascular diseases including pulmonary arterial hypertension (PAH) and atrial fibrillation (AF).

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Conclusions
Pulmonary arterial hypertension and atrial fibrillation are severe cardiovascular diseases associated with electrical remodelling including KV1.5 channel dysfunction. Thus, novel pharmacological strategies to improve the attenuated KV1.5 channel function are highly demanded. Here, we show that the chaperone S1R finetunes KV1.5 channel expression and function and S1R modulators may effectively enhance KV1.5 channel function. Our study identifies S1R as a novel pharmacological target to rescue the attenuated KV1.5 channel function in cardiovascular diseases associated with channel malfunction.

https://www.sciencedirect.com/science/article/pii/S1043661823000403?via%3Dihub

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