Anavex Life Sciences Corp (AVXL)

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Big Pharma Perspectives on Anavex

Two summers ago the parents of one of Bayer’s vice presidents stayed at our hotel, after telling the Dad all about A-273, he called his daughter and she was very much aware of Anavex and the MOA.

Of course, this raises the question of how much of Anavex science do Big Pharma insiders know and consider? Three possibilities:

1. Abject Ignorance. Big Pharma execs and science insiders know very little about Anavex; nor do they care. They haven’t seen anything from or about Anavex that gives them any concern. There are dozens of tiny start-up biotechs and they never amount to anything in the Big Pharmaceutical world.

2. Professional Dismissal. Big Pharma execs and science insiders are following the Anavex/blarcamesine story, but like the naysaying experts posting on this message board are certain that the drug has actually failed in its Alzheimer’s clinical study. Nothing to be corporately concerned about.

3. Quiet Fear. Big Pharma execs and science insiders, as science types do, have actually delved into and scrutinized all of the journal articles on the Anavex molecules, their mechanisms of action as ligands to the sigma-1 receptor, and have therefore come to recognize that blarcamesine effectively activates the sigma-1 receptor and, indeed, modulates and facilitates a diversity of downstream processes that facilitate normalized cellular health and function. These topics are discussed quietly, with circumspection, because, in regard to corporate health, they are heretical. But nonetheless true. The less said, the better....