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Re: Kb1123 post# 390715

Thursday, 12/08/2022 8:12:06 PM

Thursday, December 08, 2022 8:12:06 PM

Post# of 463440
That will be presented when Anavex provides the next analysis of the trial results. We have no idea why the company didn't provide the ADSC-ADL mean.
In reviewing the CC of Dec 5 it looks to me like Anavex choose the odds ratio to be able to compare and contrast the results to the Aduhelm which used the same metrics as part of its presentations.

I suspect that the company was expecting the use of much more demanding thresholds for the odds ratio compared to the Aduhelm data to demonstrate the much better results of the Anavex study. They did not anticipate the angst that has been created by not have the ADCS-ADL mean not presented.

When the deeper analysis is presented that will be included along with much more information.

The company has repeatedly stated that the primary endpoints were met. It appears that they thought that would be sufficient for a quick TLR presentation and choose to use the odds ration to demonstrate what they perceive as how much better than Aduhelm the results are.

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