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SkyLimit2022

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SkyLimit2022

Re: dr_lowenstein post# 537437

Tuesday, 11/22/2022 1:08:30 PM

Tuesday, November 22, 2022 1:08:30 PM

Post# of 700405
Oh yes—it is 100% about crossover. The whole question of crossover is directly related to the elimination of the internal placebo group. When there is no internal control group, external controls must be used. The FDA director’s recent article is highly relevant to the topic of crossover trial design.

Pazdur argues that external controls are both valid and necessary.

https://www.annalsofoncology.org/article/S0923-7534(22)00006-0/fulltext

Believe carefully. This is the greatest and most powerful lesson that I have learned since arriving on Earth. Examine what you believe about yourself most importantly, and then believe carefully as you interact with the world.

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