NorthWest Biotherapeutics Inc (NWBO)

[Lykiri]

I did not remember the 2015 mention by Dr. Liau.

2015
Linda Liau:

“The issue is because we have the vaccine made for everybody and we are kinda doing a somewhat invasive procedure on these patients, the FDA actually required us to have a crossover arm when the patients progress.

So uh interestingly, the whole cohort actually, um, has not reached its pre-determined event, um, how do I say this, pre-determined number of events. Um, it seems like everyone’s living longer than we would be expecting. So in reality, I think, you know, what we’re really comparing now is actually early DC vaccinations versus later DC vaccinations (big smile). And um, and I guess it’s a good thing that the patients are living longer (laughing), but it’s not really helping our study, because if the patients didn’t get anything, hopefully the differences would be bigger. So that’s kind of another lesson learned about these trials. We have to consider all these different moving parts.

Um, it was difficult to, it’s certainly more difficult to enroll a patient without a crossover arm because they are going through an invasive procedure, and then tell them we’re making vaccine for you, but then we’re just throwing it away. You know it would be difficult.

But so anyway, we’re still in the middle of this trial, it’s still blinded, and I actually don’t have any data for you right now” — Linda Liau