Anavex Life Sciences Corp (AVXL)

[Investor2014]

Had some fun making below MMSE and ADCS-ADL results montages, don't try this at home
Unless you really want to or don't trust my ocd work.



The patient graphs and identity is the same between the 57 and 109 weeks charts, but the Anavex graphics person fancied flipping around the graph colours. Refer to the little translation table top middle.

Two of the six "strong" responders, 2006 and 1009 had no unexpected therapeutic events to report. Keep that in mind when reviewing the 2nd montage below.

I think most will see that given multiple sample points that have a lot of variance, AUC trend would be a more telling method here than baseline to EOT. Had the Anavex EOT point been 53 weeks and 96 weeks the result would have been less impressive. Who knows what it would look like at say 122 weeks?

Maybe this helps see why AVATAR with baseline and two sample points make AUC a flip of a coin vs. EOT. Anavex chose a last minute change to AUC.

From the 57 weeks KEM analysis of MMSE concentration vs. improvement over baseline, we see that 2008 is the 7th high mean concentration patient not in our "strong" responders, but strangely 1009 and 1011 on next to no concentration is two of the best responders?

Now let's see if can relate these MMSE findings to the peer review paper infamous Set Theory exercise and identify the 2 "super strong" responders:



They turn out to be 1011 and 2006. 1011 had next to no concentration and 2006 was not the highest mean concentration patient. Go figure!

If this had anything to do with Donepezil then perhaps only that 1009 and1011 responded at all.