Anavex Life Sciences Corp (AVXL)

[RedShoulder]

RedShoulder ST post to Mayo re Simufilam

Mayo, I have had a question that has not been answered or opinion given that you may be able to answer since it involves a misfolded protein.

"Simufilam is Cassava Sciences’ proprietary, small molecule (oral) drug that restores the normal shape and function of altered filamin A (FLNA) protein in the brain."

Since filamin A is down stream from the S1 receptor; once Anavex 2-73 restores the S1 receptor to homeostasis, would that restore filamin A to proper folding, thus making SAVA's drug redundant and not needed?

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Mayo reply on ST:

RedShoulder absolutely, S1R mRNA expressive properties should rectify abnormalities with FLNA.

FLNA is located on the X-chromosome. In fact, it’s very close to where the MECP-2 gene is located (cause of Rett syndrome).

For more information please go see my XLID entry! :D

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RedShoulder reply on ST:

Once A2-73 Blarcamesine is approved for treating Alzheimer and becomes the strong SOC, I think SAVA's stock will become worthless. Not even needed as a combo to A2-73 Blarcamesine.