Amarin Corp Plc (AMRN)

[Tatsumaki]

Amarin needs a MOA in the worst way.

Statins had cholesterol. High cholesterol is bad and causes heart issues. Take your statin and lower cholesterol. Dr, Insurance Co's and patients all had an easy feedback loop that the drug was in fact "working". The drug continues to sell billions even with generics globally.

Lovaza had that with Tgs. Same concept but FDA pulled the high Tg = bad heart issue concept leaving Amarin hanging. V was for sure going to be Lovaza 2.0 to beat out new generic L competition. "Lowers Tgs without raising LDL=C!" as the pitch. Reduce It was just the validation that it had the heart benefit everyone linked with Tgs at the time and now they're desperately trying to sell that on its own and it's not flying.

Another study validating Reduce It isn't going to change anything. Big money doesn't accept the fact that "it just works". They want to know how. They want a way to verify it's working along the way, not some 5+ year maybe that it'll reduce MACE. Meanwhile, Amarin is running out of time on the exclusivity of the drug in all markets.

Measuring blood levels of EPA isnt going to cut it. AA/EPA isnt going to cut it. That just kicks it back to the dietary supplement realm. It'll just become "
take whatever is cheapest and we will test levels". Doctors will try people out on numerous supplements and simply test. Amarin will just get swamped by off the shelf supplements or other companies with a formulation that beats the patent. Likely why Amarin seems to have avoided pinning this all on serum EPA until lately.

Where Amarin management has completely failed is identifying why this is actually working and marketing THAT to Doctors and Insurance companies. Or they know, and cant be reasonably protected.