Charlotte's Web Holdings Inc (CWBHF)

[DarthYoda]

Bunch of stuff here including a congressional letter to the FDA and a couple papers. One paper shows potent anti-inflammatory effects comparable to but different from Dexamethasone, and the other shows that CBD causes "blooms" of good gut bacteria and more...

Lead sponsors of H.R. 6134, the CBD Product Safety and Standardization Act, are calling on the @US_FDA to provide answers as to why the agency has failed to establish a regulatory framework for #hemp-derived #CBD.

Learn more and take action👇https://t.co/QeepQkRZmz

— US Hemp Roundtable (@HempRoundtable) September 15, 2022

https://hempsupporter.com/assets/uploads/Rice-Griffith-FDA-TA-Response.pdf

https://hempsupporter.com/news/house-leaders-slam-fda-technical-assistance-on-hemp-legislation

"Comparison of the in vitro Anti-Inflammatory Effect of Cannabidiol to Dexamethasone":
16 September 2022

Background: Cannabidiol (CBD) is a non-psychoactive phytocannabinoid constituent of Cannabis sativa with pain-relieving and
anti-inflammatory properties. With the emphasis on natural ingredients in cosmetics, CBD has become a new cosmetic ingredient due
to its ability to alleviate inflammation. However, in-depth studies that directly compare the effective mechanism and the therapeutic
potential of CBD are still needed.

Purpose: The aim of the present study was to investigate the anti-inflammatory effect of CBD in lipopolysaccharide (LPS)-stimulated
RAW264.7 macrophages and compare it to dexamethasone (DEX).

Methods: RAW264.7 macrophages in the logarithmic growth phase were incubated in the presence or absence of LPS. After that, the
production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-a) were measured. A luciferase reporter assay
for nuclear factor kappa B (NF-?B) was performed, and the phosphorylation levels of the mitogen-activated protein kinase (MAPK)
and NF-?B signaling pathways were measured.

Results: The present study indicated that CBD had a similar anti-inflammatory effect to DEX by attenuating the LPS-induced
production of NO, IL-6, and TNF-a. However, only CBD attenuated JNK phosphorylation levels, and only DEX attenuated IKK
phosphorylation levels.

Conclusion: These results suggested that CBD and DEX exhibit similar anti-inflammatory effects on LPS-induced RAW264.7
macrophages mainly through suppressing the MAPK and NF-?B signaling pathways, but with different intracellular mechanisms.
These findings suggested that CBD may be considered a natural anti-inflammatory agent for protecting skin from immune disorders.

https://www.dovepress.com/comparison-of-the-in-vitro-anti-inflammatory-effect-of-cannabidiol-to--peer-reviewed-fulltext-article-CCID

"Study Points To Potential Benefits Of CBD For Menopausal Women":
September 16, 2022
https://hempgazette.com/news/cbd-menopause-study-hg1785/

Here is the actual paper with an excerpt. Lots of other interesting info in this one. It's worth a read thru...

"Cannabidiol-Treated Ovariectomized Mice Show Improved Glucose, Energy, and Bone Metabolism With a Bloom in Lactobacillus":
21 June 2022

Interestingly, CBD promoted a bloom in Lactobacillus species. Prior studies indicated that probiotic Lactobacillus treatment may protect against bone loss by reducing gut permeability and levels of proinflammatory cytokines in the gut, circulation, and bone.

https://www.frontiersin.org/articles/10.3389/fphar.2022.900667/full