Food as Medicine

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>>> Abstract 706: Dietary Lectins Contribute to Coronary Artery Disease in Humans via an 1L-16 Autoimmune Mediated Response as Shown by the PULS ACS Risk Score


https://www.ahajournals.org/doi/10.1161/atvb.39.suppl_1.706


Steven R Gundry

Originally published19 Jul 2019

Arteriosclerosis, Thrombosis, and Vascular Biology. 2019;39:A706

Abstract

Interleukin 16 (IL-16) is a chemoattractant released by endothelial and other cells to attract activated T cells. It has previously been shown to have expression in many autoimmune diseases (AI). Based on our previous reports using elevated adiponectin levels of 16 ug/mL to predict lectin sensitivity, and showing an association between lectins and AI causation, we have treated a large patient population with known autoimmune disease confirmed by markers. Our continuing hypothesis is that coronary artery disease is an autoimmune process. We reported last year that the PULS Cardiac Test (GD Biosciences Lab, Irvine, CA) a validated blood test for predicting 5 year risk of acute coronary syndrome (ACS), showed that IL-16 elevation was the first or second highest risk factor for ACS in these AI patients. The PULS tests ranks 9 biomarkers, including IL-16, MCP-3, Eotaxin, CTACK, sFas, Fas Ligand, HGF for ACS risk, ranking each biomarker from lowest to highest level contributing to risk.

We subsequently enrolled 278 pts, aged 35 to 91, M/F ratio 1/1, who were positive for elevated IL-16, without AI, and with elevated PULS scores, in our clinical dietary program, The Plant Paradox, which consists of removing major dietary lectins from the diet, including grains, beans, nightshades, peanuts, and using large amounts of olive oil as fat; and measured PULS markers and Risk Score both at baseline and 6 months follow up.

PULS Risk Score at baseline was 23.5+/-8 (normal 4+/-2) with IL-!6 contributing 75% to the risk score. At 6 months, PULS Scores fell to 8+/-5 with IL-16 contributing only 20% to total PULS risk score.

We conclude that based both on IL-16 levels and PULS Scores dramatically falling during six months of lectin avoidance, that this provides further evidence to support an autoimmune contribution to coronary artery disease causation at the endothelial level via T cell activation and attraction, most likely caused by dietary lectins. Removal of dietary lectins reduces risk of ACS and should be recommended nutritional therapy.

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