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RedShoulder

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Re: MayoMobile post# 372070

Monday, 08/29/2022 10:20:57 PM

Monday, August 29, 2022 10:20:57 PM

Post# of 460256
Mayo, I have had a question that has not been answered or opinion given that you may be able to answer since it involves a misfolded protein.

"Simufilam is Cassava Sciences’ proprietary, small molecule (oral) drug that restores the normal shape and function of altered filamin A (FLNA) protein in the brain."

Since filamin A is down stream from the S1 receptor; once Anavex 2-73 restores the S1 receptor to homeostasis, would that restore filamin A to proper folding, thus making SAVA's drug redundant and not needed?

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