Todos Med Ltd (TOMDF)

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TODOS MEDICAL ANNOUNCES PREPRINT OF DATA FROM FIRST 100 PARTICIPANTS IN IRB-WAIVED MARKET RESEARCH STUDY OF SUPPLEMENTATION WITH TOLLOVID IN LONG COVID
Todos Medical Ltd.
Fri, August 19, 2022, 5:30 AM

Todos Medical Ltd.
Fri, August 19, 2022, 5:30 AM
In this article:

New York, NY, and Tel Aviv, ISRAEL, Aug. 19, 2022 (GLOBE NEWSWIRE) -- via NewMediaWire -- Todos Medical, Ltd. (OTCQB: TOMDF), a comprehensive medical diagnostics and related solutions company, today announced that its majority-owned joint venture 3CL Pharma Ltd. reported the preprint in ResearchGate of results from the first 100-participant study from an IRB-waived market research study entitled “The Value of 3CL Protease Inhibitor Supplementation in Long Haul Syndrome Patients?” overseen by Dr. Dorit Arad in concert with Andrew A. Blumenthal, RN ADS. Participants in the study are primarily patients with Post-Acute Sequelae of COVID (PASC, or “Long COVID”) as well as participants with acute COVID infection. The results to date indicate the participants appear to experience benefit after supplementation with 3CL protease inhibitor immune support supplement Tollovid™.


Todos Medical Ltd.
Fri, August 19, 2022, 5:30 AM
In this article:

TOMDF
+3.23%

Todos Medical Ltd.
Todos Medical Ltd.
New York, NY, and Tel Aviv, ISRAEL, Aug. 19, 2022 (GLOBE NEWSWIRE) -- via NewMediaWire -- Todos Medical, Ltd. (OTCQB: TOMDF), a comprehensive medical diagnostics and related solutions company, today announced that its majority-owned joint venture 3CL Pharma Ltd. reported the preprint in ResearchGate of results from the first 100-participant study from an IRB-waived market research study entitled “The Value of 3CL Protease Inhibitor Supplementation in Long Haul Syndrome Patients?” overseen by Dr. Dorit Arad in concert with Andrew A. Blumenthal, RN ADS. Participants in the study are primarily patients with Post-Acute Sequelae of COVID (PASC, or “Long COVID”) as well as participants with acute COVID infection. The results to date indicate the participants appear to experience benefit after supplementation with 3CL protease inhibitor immune support supplement Tollovid™. The publication preprint can be viewed at: https://www.researchgate.net/publication/362791461_VALUE_OF_3CL_PROTEASE_INHIBITOR_SUPPLEMENTATION_1_The_Value_of_3CL_Protease_Inhibitor_Supplementation_in_Long_Haul_Syndrome_Patients_The_Value_of_3CL_Protease_Inhibitor_Supplementation_in_Long_Haul_Sy.

ABSTRACT

In moderate to severe acute COVID-19 and Long Haul Syndrome (LHS), innate and adaptive immunological dysregulation is frequently observed and can persist for months, leading to a significant decline in clinical status and quality of life for many individuals. One hallmark of an over-exuberant immunological response is cytokine hyperactivity ('cytokine storm') that can lead to severe acute respiratory distress syndrome in certain patients. Reduced immunopathology and clinical resolution of the acute disease, on the other hand, appear to be associated with a powerful early innate antiviral response coupled with viral neutralization in such patients. The mechanisms by which the SARS-CoV-2 virus may subvert the host immune response are the subject of focused research in an effort to define virally-encoded factors that might be targeted for therapeutic intervention. One such target is the 3CL protease (3CLpro, Main protease, Mpro, Nsp5), sometimes referred to as the 'Achilles heel' of the SARS-CoV-2 virus. 3CLpro is essential to viral replication, and can also have direct, deleterious effects on the host's immune response, potentially via NEMO inactivation, thereby impacting the ability to resolve infections. Viral protease inhibitors have been used in several licensed oral medications and are well-validated therapeutic targets for the treatment of hepatitis C virus (HCV) and the human immunodeficiency virus (HIV). Indeed, pharmaceutical 3CLpro inhibitors are currently the most prescribed antiviral therapy for COVID-19. Here, through a series of 104 case study respondents in an IRB-waived market research self-reported questionnaire, we highlight emerging evidence concerning positive clinical and immunological impacts of supplementation with Tollovid, a natural, botanically-based immune cleanse/support dietary supplement with potent 3CL protease inhibitory activity in vitro, first reported here, in patients suffering from Acute COVID and LHS-related symptoms.

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