Anavex Life Sciences Corp (AVXL)

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Short Mention Regarding Today's Trivia

Earlier today we were examining the new peer-reviewed entry in Nature: https://www.nature.com/articles/s41419-022-05153-5

We believe this is the most detailed and important peer-reviewed publication to date regarding the quest for understanding Blarcamesine’s mechanism of action.

Earlier we posted a question in multiple investment/enthusiast forums regarding an excerpt of the paper. We wanted to know if anyone could answer why SOTC Analytics was so enthralled by the following excerpt: “Neurons are highly dependent on oxidative metabolism for their functions and for the transmission and processing of information, exposing them to the burden of enhanced cell stress”.

While we are looking forward to posting the rest of our notes later this week, we wanted to share the answer to our question below as it directly pertains to Anavex’s AAIC 2022 release of Blarcamesine-caused gene upregulation.

40 of the 65 genes (62%) called out in the AAIC AD/PD upregulated gene clustering(s) have direct influence over cellular respiration (oxidative metabolism) processes.

Cellular respiration is the way ATP and water is created from nutrients, protons, electrons, and oxygen in the ELECTRON TRANSPORT CHAIN.

In the electron transport chain, it is normal for water to be synthesized by four electrons and four protons reducing oxygen into water. However, occasionally, and spontaneously, transfer of only one or two electrons morph to create dangerous reactive oxygen species (ROS). ROS are harmful to cells because they oxidize proteins and cause mutations in DNA. ROS contribute to disease and are thought to be a primary cause of aging. To counter ROS, cells are equipped with numerous antioxidants and agents which act to detoxify ROS and limit damage to cells.

The electron support chain has a very wide mechanism with many moving parts. Impediment of any stage halts the rest of the process.

Intriguingly, the 40 genes upregulated by Blarcamesine are part of the entire electron support chain, from the beginning of the process to the middle, and the end. Additionally, some of the genes upregulated by Blarcamesine directly maintain other functions within the chain. Not only is Blarcamesine directly aiding the support chain, but the compound is also enabling the genes responsible as custodians for the processes. This should allow the process of creating ATP and water for cells to re-regulate, and hypothetically continue normalizing even after a dosing regimen is completed.

In short, Blarcamesine has massive implications in the way our cells can create energy and reduce damage from ROS.