Anavex Life Sciences Corp (AVXL)

[Steady_T]

To put a bit more perspective on that. Missling said 85 to 90% WT patients and the variant gene types also responded.

Most drugs get 30 to 40% response rate or less. So far it is looking like the Rett response rate was much better than that. The AD response rate is still open to debate. Clearly there were a few that responded very well, some more showed some effects and others that didn't respond. However that trial was not at max dosage. Until we get a look at the P3 trial we don't really have a good understanding of how well 2-73 is doing treating AD. We do know how well the current SOC works. So a 30% response rate would be a major breakthrough.

For an outcome affecting quality of life, ½ of a standard deviation is considered to be a minimal clinically important difference [13]. Out of 17 common pharmacological treatments examined, only 11 met this threshold. In four of them efficacy was represented by surrogate outcomes, such as diastolic blood pressure or fasting plasma glucose, and not patient-oriented outcomes, such as pain, mortality or adverse events. Therefore, patients might not have experienced substantial benefits related to their well-being and quality of life after therapy with some of these drugs.

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-015-0494-1