Sunday, August 07, 2022 2:40:56 PM
When you say manufacturing will determine the number of parallel trials, I don't believe that it would be that great a problem to put a single FlaskWorks unit at every trial site. With the FlaskWork unit taking roughly 1 week for each patient entered into a trial I believe that one trial facility could be doing several different cancer trials and still adding 1 patient in say each of 8 different cancers every 2 months. If you had 100 different trial sites operating in that manner it wouldn't take very long at all before having say 300 patients with 8 different cancers enrolled from 100 trial sites. TIhe key is the FlaskWorks unit on site. I believe that most clinical sites would have the other equipment necessary to support the FlaskWorks unit in such clinical trials.
If my math was right, in 6 months time you'd have 300 patients in each of 8 different cancer types in trial with sufficient vaccine to complete the trial for all of them. At that point you could start on 8 more different forms of cancer so at the end of one years time potentially 16 different types of cancer could be in trials from those 100 sites each with just one FlaskWorks unit.
I'm not saying it would be done this way, but I believe it's one way it could be done without the logistical problems of transporting the tumors, etc. to remote production sites. With proper scheduling the vaccine could be made immediately after the surgical removal of the tumor if the leukapheresis was done prior to the surgery.
If there is something wrong with the logic I've applied here please let me know what it is.
Gary
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