Thursday, August 04, 2022 6:36:29 PM
To address your other post, CD-19 is expressed in all B cells. This includes the healthy B cells. So when you target CD19 you are not only killing the cancer cells you are also killing healthy cells. Hence the toxicity with CAR-Ts. I would assume this is the reason CD19 is not included as a target in MultiTAA. The antigens Marker is targeting are specifically overexpressed in cancer cells, not healthy cells. This is just my understanding.
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Recent MRKR News
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