Friday, July 29, 2022 12:16:04 PM
Thanks Dew. It looks good to me.
So if we take the mid-zone for half-life of 18 hours, let's look at 200mg and 400mg doses on delta in the lung.
Estimated Lung levels, fold higher than EC50 after last dose:
200mg: 6 fold at 18hrs, 3 fold high a 36hr and 1.5 times higher at 54 hrs.
400mg: 24 fold at 18hr, 12 fold at 36hr, 6 fold at 54hr, 3 fold at
72hr and 1.5 fold after 90hrs.
That means people might be less likely to suffer from rebound like sometimes seen with Paxlovid. I wouldn't be surprised if the 200mg dose is used and perhaps for 7 days rather than 5 days.
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