Amarin Corp Plc (AMRN)

[sts66]

I never believed in that "natural fats" like those found in red meat and butter were bad for you - humans ate those foods for a couple thousand years, we adapted to deal with it, or even need it - what really happened that increased CVD was the explosion of vegetable oils in all kinds of processed foods - humans didn't start consuming those man-made fats until the last 50-100 years. Throw in substituting HFCS for real sugar and you have a massive increase in obesity and CVD.

The low baseline Lp-PLA2 levels are a real puzzler to me, around 130 is only a few points from optimal levels - they went up +25% - but does a level of 163 indicate higher CVD risk? We don't know the answer, because levels in V patients didn't change at all. If something like hs-CRP went from 2.3 to 3.4 that's a large % change, but 3.4 isn't really a high level. I think what Bhatt tried to point out is that the only clear correlation of CVD risk R-IT data revealed was that the level of serum EPA is what matters - they went up 400% in V patients.