Blarcamesine Dosing for Prophylaxis
I, and others, have posted messages theorizing that blarcamesine (Anavex 2-73) will be used not only to treat existing cases of various CNS diseases but also will be prescribed and administered for prophylactic purposes, where the drug is taken before any disease symptoms appear, so as to prevent their onset. Disease prevention; prophylaxis.
Important question: what dosages and dose frequencies would be required to attain prophylaxis? Would they have to be at the same level and frequency as required for an existing disease state? Or, could prophylaxis be functionally attained at far lower doses, taken less frequently?
I’m certain that Anavex has investigated and knows the half-life of a dose of blarcamesine. If it’s short, say 8 to 4 hours, daily dosings, perhaps twice a day would be required to maintain functionally useful systemic concentrations.
But what if the functional half-life of blarcamesine is 24 hours or longer? Because it’s a sigma-1 receptor ligand, it chemically binds to that protein and may stay functionally attached for extended periods. For prophylaxis, it’s very possible that smaller doses, at more lengthy frequencies will be sufficient. Instead of taking a 50mg tablet of blarcamesine each day (a presumed dosing regimen for an existing CNS disease), for prophylaxis merely 20mg, taken twice each week would be effective. Ideally, a small dose taken every Monday morning would prevent the onset of various CNS and other diseases.
“Good morning! This email is from your friends at Anavex. It’s Monday, so be sure to take this week’s blarcamesine capsule.”
Monday’s become the Stay Healthy Day of each week.
