Amarin Corp Plc (AMRN)

[couldbebetter]

Jasbg, The real problem is simple. Vascepa works very well with Statins which
when combined have a synergistic effect. However, mineral oil with a statin alone
seems to block the effectiveness of statins. Early on the theory was that mineral
oil reduced the absorption of statins. I think that is the crux of the problem.

AMRN and the FDA has taken the attitude that the R-I results and other studies
are so positive as to negate the "minor" impact that mineral oil had on results.
The other side claims that because MO may have affected statins that R-I results
are invalidated.

My opinion is that AMRN management botched the attempt to push back against
the Nissen/STAT narrative. One pet peeve of mine are the statements that the
mode of action for Vascepa is unknown. The truth is that there are several
modes of action such as being anti-inflammatory and plaque reduction being
among them. What is needed for AMRN is new (BP) management that will
be able to get across the narrative that Vascepa is very safe and very effective.