Kezar Life Sciences Inc (KZR)

[Whalatane]

It was a P 2 trial and there was no mandate to lower steroid use....altho some did anyway .
Remember this was largely a refractory population , there was no induction therapy and eGFR remained stable from baseline to end of trial .

Re drop outs ..this trial was being run during the worst of the Omicron surge . Patients needed to come to the clinic for their weekly sub Q injection .Hospital visits for all procedures were down as patients avoided hospitals if they could.

The P 3 trial ( or trials ) will be in a larger more diverse LN population ...maybe 2 trials ...one with induction therapy the other not and where reducing steroid use will be mandated

Just my take
Kiwi