Anavex Life Sciences Corp (AVXL)

[abew4me]

Good post. After looking up the definition of "heteromer", I fully agree with the unique binding effect between the S1r and the M1 receptors.

heteromer: "The ligand binding properties and intracellular trafficking pathways of GPCR heteromers usually show elements from both parent receptors, but may also produce quite unexpected pharmacological effects, making such heteromers an important focus of current research.[18][19][20][21][22]"

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abew4me
Member Level
Monday, May 09, 2022 3:16:31 PM
Re: Steady_T post# 359702

Post# of 364025

Quote: "In fact there are a number of ways that the S1 receptor can be agonized and it appears that each different way has different results to a greater or lessor degree."

Agree 100%. I believe the Anavex team has thoroughly studied and identified the most potent binding points of the S1R and the adjoining muscarinic receptors.

This is the HOW and WHY of Blarcasemine's efficacy...especially when comparing it to other S1R drugs.