Crispr Therapeutics AG (CRSP)

[jondoeuk]

Either they make all the edits at the iPSC stage or make a few foundational edits. If it's the latter there would be at least a second round of engineering, going through the sub-clones and then banking.

As for any DNA mutations/translocation they are detectable in the clonal population and can be screened out. I know FATE had to screen over 500 clones to find just a single one to create FT536.