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New Evidence for Blarcamesine-induced Autophagy for Alzheimer’s

Evidence mounts. Alzheimer’s is not caused by “amyloid buildup outside of brain cells.” A new paper finds that in Alzheimer’s, lysosomes, filled with acidic enzymes involved in the routine breakdown, removal, and recycling of metabolic waste from everyday cell reactions, are dysfunctional.
https://www.eurekalert.org/news-releases/954383

This particular autophagy, removal of wastes inside cells, is compromised, which allows the accumulation of toxic wastes inside the cells, thereby disrupting normal cell functions. In brain cells, Alzheimer’s results.

Here are the definitive statements:

“Our results for the first time sources neuronal damage observed in Alzheimer’s disease to problems inside brain cells’ lysosomes where amyloid beta first appears,” says study lead investigator Ju-Hyun Lee, PhD.

“Previously, the working hypothesis mostly attributed the damage observed in Alzheimer’s disease to what came after amyloid buildup outside of brain cells, not before and from within neurons,” says Lee, a research assistant professor in the Department of Psychiatry and NYU Langone Health and research scientist at Nathan Kline.

“This new evidence changes our fundamental understanding of how Alzheimer’s disease progresses; it also explains why so many experimental therapies designed to remove amyloid plaques have failed to stop disease progression, because the brain cells are already crippled before the plaques fully form outside the cell,” says study senior investigator Ralph Nixon, MD, PhD.

“Our research suggests that future treatments should focus on reversing the lysosomal dysfunction and rebalancing acid levels inside the brain’s neurons,” says Nixon, a professor in the Department of Psychiatry and the Department of Cell Biology at NYU Langone, as well as director of the Center for Dementia Research at Nathan Kline.

“...future treatments should focus on reversing the lysosomal dysfunction....”

Really? That’s exactly what blarcamesine facilitates: healthful, normalized autophagy, cellular waste clearing, accomplished by properly-functioning lysosomes.