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Re: Investor2014 post# 362055

Wednesday, 06/01/2022 6:45:33 PM

Wednesday, June 01, 2022 6:45:33 PM

Post# of 463849
Tanya is not a typical participant in a ANAVEX's Blarcamesine trial. Tanya is 41 years old and has had 3 decades of deteriorization from Rett syndrome. Tanya was titrated to the maximum dose for the Rett syndrome AVATAR trial, then she contracted a COVID infection and needed to go into the hospital to treat the COVID infection for 3 weeks (she had a severe COVID infection) then a couple of months later she had pneumonia. They believe that she had/has long COVID.

According to trial protocol she needed to start titration after the AVATAR trial (7 weeks) was completed, when she started the OLE trial. This was after she contracted COVID. Her COVID infection had/has understandably adversely affected her tolerability to Blarcamesine during the OLE trial.

GOD bless,
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