NorthWest Biotherapeutics Inc (NWBO)

[GermanCol]

Anybody else think the early vanguard group is the one that primarily makes up the 24 unidentified mgmt in the noncrossover group?

Me, I think that is the case. From JTM article:

The MGMT gene promoter was methylated in 39.6% of patients (n=131) and unmethylated in 48.9% (n=162), with information not available for 11.5% (n=38; the missing data relates to the early patients enrolled a decade ago)

I also want to clarify that I don´t know if the 35 non crossover patients as a whole did well or better than the other patients. What I have been saying is that from my calculations I conclude that there is a higher percentage of MGMT Methylated and IDH-1 mutated in that group. And these patients are expected to do better, so in case the whole group of 35 did better than the others, there is no reason to worry about.

I agree that in this group there should have been also progressors that didn't make it to crossover and didn't do well. Also I think in this group there are patients that opted for other treatments after progressing and probably weren't followed anymore.