NorthWest Biotherapeutics Inc (NWBO)

[skitahoe]

Thanks Dr. Bala,

I would think that a limited number of DCVax-L doses would be made, so at some point it would no longer be applied, and hopefully is no longer needed. I do wonder if some vaccine is available and more is deemed to be needed if some of the bioreactors being used in various capacities may be capable of such production.

I have PSTI stock options, they're an Israeli company that's trying placental cells where they're making 20,000 doses of their drug in their bioreactor. They also recently signed a partnership to use the reactors to make steaks and other meat forms. I'll be interested in how well they can do. I really don't know much about how it's done, but I find it fascinating and believe that such things are possible.

I don't know whether at the time they make the DCVax-L they use a limited amount of the tumor lysate, and can hold additional in cryogenic storage should more be needed, or if they make as much as possible from the tumor they're working with. I would think that in the FlaskWorks unit a specific amount of the lysate would be used, so additional could be held for the future if needed. On the other hand if additional surgery was required, I think they'd make new vaccine from the tumor that was just surgically removed. Of course if DCVax-Direct is approved, it might be used as well.

We'll really not know what we actually have here until both products have been tested in a variety of cancers. Any company that either partners, or submits a buyout offer, could be getting far more than they can even dream of if our vaccines end up becoming part of the SOC in many cancers.

Gary