Anavex Life Sciences Corp (AVXL)

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Old science versus new science.

An anti-amyloid beta AD drug gets 'fast track' status from the FDA.

Should anyone be surprised?

For this, everything fits. Once again, but this time so much more effectively (it is presumed), waste proteins, beta-amyloids and tau tangles, are being effectively targeted. This time, by a drug that is taken orally. By some sort of induced immunology, the waste proteins associated with (not necessarily the cause of) Alzheimer’s will be reduced or eliminated. It’s just so wonderful. For the waste proteins crowd (all of conventional medicine), effective and safe treatment of Alzheimer’s edges ever closer.

As I’ve claimed so many times before, two professions, historically, have always resisted and rejected any “new knowledge” that contradicts accepted, known precepts. Understandably, farmers are always reluctant to take on new farming practices that are “unproven” and are against what is known and practiced. Case in point, no-till cultivation of row crops. Medicine always looks to the historical experts to understand how medical things work. The writings of ancient physicians in Greece and Rome guided (well, confined) medical knowledge until the Renaissance. Took a while to believe that the heart actually circulated blood through the circulatory system. Lister and Pasteur claimed that diseases weren’t caused by re-breathing bad air at night, but microscopic “germs” were the cause.

Today, medicine is stuck in the amyloids, waste proteins rut. It will remain there until Alzheimer’s is effectively treated for several years by something targeting something else. The preclinical therapeutic and safety data of blarcamesine against Alzheimer’s are, per se, overwhelming. But, they are summarily rejected. “Merely murine results,” from lab rats. “Only anecdotal,” with individual data points from “a few individuals” who can’t be relied upon for authentic clinical accuracy. “Mere chance.”

Blarcamesine works entirely differently. Anyone wanting to understand how the drug works against Alzheimer’s has to take on new knowledge; none of which was taught in high school biology classes, college human physiology classes, nor found in any med-school textbook.

Sigma-1 Receptor Protein Biology. Unknown by any medical experts. As new to medicine today as was the “germ theory” in the 1860s and 70s. It took decades for the germ theory to be fully accepted and applied. Most likely, it will take a decade for the waste proteins explanation of Alzheimer’s to be discarded — after blarcamesine becomes the SOC (standard of care).