Lexaria Bioscience Corp (LEXX)

[Abundance88]

Buccal Nicotine Absorption Studies from animals to humans

Here's Chris' statements on Nicotine studies from the Letter to Shareholders from earlier this year:


"In November 2021 we issued study results that demonstrated yet another first for Lexaria: in an animal study we evidenced that DehydraTECH was effective in promoting superior nicotine drug delivery characteristics in sublingual/buccal (oral) tissue.

DehydraTECH was originally developed to promote more efficient delivery of fat-soluble drugs across the intestinal wall, so our findings demonstrating its effectiveness also in enhancing sublingual/buccal (oral) absorption greatly enhances the value proposition for our technology for the oral nicotine products sector. This nicotine study was noteworthy not just because we delivered much higher levels of nicotine, more quickly; but also because we made this breakthrough utilizing buccal tissues of the mouth, gums and throat instead of through our traditional delivery through the intestines.

This was yet another opportunity demonstrating the versatility of DehydraTECH to work effectively in different parts of the body and opens doors to drug delivery through products such as lozenges, sub-lingual tablets, and other forms of non-swallowed oral products.

Because of this important new discovery for DehydraTECH, we are launching a very similar study in humans expected to start soon. If we can demonstrate similar performance of nicotine absorption through the sublingual/buccal tissue in humans, we feel that DehydraTECH will have advanced another big step in the direction of commercial applicability".

Here's the link to the 36 person nicotine study just announced.
https://ir.lexariabioscience.com/news-events/press-releases/detail/170/lexaria-provides-update-on-human-nicotine-study-nic-h22-1

Here's the results from last year's successful animal study.
https://ir.lexariabioscience.com/news-events/press-releases/detail/153/lexaria-oral-nicotine-study-nic-a21-1-delivers-outstanding