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Lexaria, undervaluing the MTA
https://4495825a-d729-4d8f-ade8-e78f828e1c8d.usrfiles.com/ugd/449582_1b5e4509baf640a8aafc1921960be7b7.pdf
It certainly hasn't been going up since that 2 million offering @ $1 a few weeks ago.
Is this company circling the drain?
https://4495825a-d729-4d8f-ade8-e78f828e1c8d.usrfiles.com/ugd/449582_ba25db90413a4248a3f19f6d520a99f9.pdf
Question of the Week – is all the news on GLP-1 drugs good for Lexaria?........................................p 4
....yeah we can see the stock price too, we know its under 2 bucks, whats your point?
That is more accurate description of what LEXX is about.
Not a cannibus stock
I have mentioned it earlier too, whenever f...kd up Odashi letter shows up, it is followed upwith more dilution
This raise at $1 for 2 mm says they just want to survive for another year plus and milk this cow. Of the $2 mm raised one mil goes to the top 3 mgt folks in the next 12 months. If the MTA had any merit - why raise and dilute with $6mm COH? MGT and BOD should go to prison for the complete mismgt of this co. IMO GLTA WHO ARE IN TOO DEEP TO WALK
MORE CASH FOR INFLATED SALARIES AND SHARES TO LINE THEIR POCKETS - F THE INVESTORS -- TOP MGT MAKING $1 MILLION A YEAR PLUS ALL TH E PERKS
https://4495825a-d729-4d8f-ade8-e78f828e1c8d.usrfiles.com/ugd/449582_b00d18d5ada348aba595b6b8022633fb.pdf
Lexaria Bioscience (NASDAQ: LEXX): the new information I have this week is management does not think news on the Material Transfer Agreement (MTA) is late. Chief Executive Officer Rich Christopher said his expectation has been news could be expected in April, May and June period for quite some time. This is excellent news because it means to me that a decision has been made by the unidentified party to the MTA. In the meantime, LEXX announced another direct comparison between their DehydraTECH-lirag lutide with Saxenda® branded liraglutide. A few days earlier, LEXX had announced the start of dosing for this study. This work is being done as part of GLP-1-H25-5 underway in Australia. At the present time, liraglutide is only available injectable form under the brand names Saxenda® and Victoza® both owned by Novo Nordisk. Saxenda® contributed US $1.0 billion in sales and Victoza® added another US $0.8 to Novo Nordisk’s top line. Also, a part of the Australian study added on due to positive results is the study of DehydraTECH-processed Zepbound® with Zepbound® owned by Eli Lilly. Because of projects like this, I continue to believe Lexaria Bioscience (NASDAQ: LEXX) remains a “hot buy” and I would think a little patience is certainly warranted. With a market cap under US $25 million, LEXX seems exceptionally cheap to me given the strong expected news flow and positive momentum in the share price over the past few weeks.
The Next GLP-1 Is A Pill: What to Expect for Weight Loss
Dave Knapp
Mar 7
The world of GLP-1 medications is evolving, and Eli Lilly’s orforglipron is leading the next wave. Unlike Rybelsus, which was the first oral GLP-1 medication but still a peptide, orforglipron is the first non-peptide oral GLP-1 receptor agonist. This key difference means it is more stable in the body, easier to absorb, and potentially offers a new level of convenience for people needing weight loss or blood sugar control.
Lilly's oral GLP-1, orforglipron, demonstrated statistically significant efficacy results and a safety profile consistent with injectable GLP-1 medicines in successful Phase 3 trial
https://4495825a-d729-4d8f-ade8-e78f828e1c8d.usrfiles.com/ugd/449582_51b6f0993850407ab84754550c5874cb.pdf
"Lexaria Bioscience (NASDAQ: LEXX): as I have been pointing out, LEXX has several significant devel opments on several fronts. The Material Transfer Agreement (MTA) is slightly late but I am not worried yet. I think agreements that require additional scientific work to be done and results to be analysed can be for to six weeks late and we are, say, one third of the way along the timeline. LEXX announced another direct comparison between their DehydraTECH-liraglutide with Saxenda® branded liraglutide. A few days earlier, LEXX had announced the start of dosing for this study. This work is being done as part of GLP-1-H25-5 underway in Australia. At the present time, liraglutide is only available injectable form under the brand names Saxenda® and Victoza® both owned by Novo Nordisk. Saxenda® contributed US $1.0 billion in sales and Victoza® added another US $0.8 to Novo Nordisk’s top line. Also a part of the Australian study added on due to positive results is the study of DehydraTECH-processed Zepbound® with Zepbound® owned by Eli Lilly. Because of projects like this, I continue to believe Lexaria Bioscience (NASDAQ: LEXX) remains a “hot buy” and I would think a little patience With a market cap under US $25 million, LEXX seems exceptionally cheap to me given the strong expected news flow and positive momentum in the share price over the past few weeks. This is a time to “buy-buy,” NOT “bye-bye.”
Ted Ohashi
FYI: Stocktwits has a more active LEXX board than here. See you there.
CBD is such a niche segment though, that isnt going to pump this stock.
Thank you Shawking -- GLTA
SORRY FOR TH E CAPS BUT I NEEED NEW GLASSES. MY GUESS IS THAT A BIG PHARMA ( ASSUMING IT IS A BIG PHARMA) WILL WANT TO DO SOME EVALUATION OF THEIR OWN (ALTHOUGH I HOPE NOT AS IT WILL ADD A GOOD AMOUNT OF TO ANY DEAL BEING MADE). THE HAIL MARY IS A DEAL IN THE WEEKS AHEAD -- IF THEY RUN A TRIAL OR TRIALS OF THEIR OWN THEN I BELIEVE WE ARE NOT TALKING WEEKS BUT MONTHS OR QUARTERS. I HAVE BEEN BUYING SHARES FOR YEARS AND SOME MORE RECENTLY AND HAVE NOT SOLD ANY...MY HOPE/PRAYER/BELIEF IS THAT ONE GOOD DEAL WILL BREAK THE DAM AND OTHERS WILL FOLLOW. I WILL MAKE A NICE PROFIT OR HAVE A BIG WRITE OFF. I DOUBT OUR CEO KNOWS. HOW THINGS ARE GOING TO GO. FWIW - IMHO - GLTU
Whats your read on the MTA thats supposedly in the offing with thir DehyraTech?
LEXY has been doing everything well, CBD nicotine etc but only to the extent that no big pharma cares. Too many rat studies are done by many companies with great results that no one will buy into. For years, lexy has been a rudderless ship steered by an overpaid under performing CEO (BUNKA) coupled with Dr John that acts as though Lexy is his personal piggy bank ( while making $300k plus a year). They have never picked an area or two and done something to the point anyone would want to buy in. Salaries for the top three guys today are about a $million a year with results not worth a dime as of today. (PPS $1.38 today with a 30 for 1 reverse split) . I hoped the new CEO would steer the ship but I believe he is a finance guy charting a course to nowhere just like Bunka. I am in too deep to jump ship so I wait for a "Hail Mary " play to get my money back - although with each passing day I see more of my money wasted. Will sit and wait for a miracle at this point - with the latest study. GLTA
Great results. Big pharma is likely impressed although SP manipulators seem to be enjoying themselves today! Be glad to get into some volume from investors that want to hold for more than a quarter at a time!
500k shares exchanged in the first two minutes of trading?
What's going on?
CB has been and is a self serving leech. - over paid and underperforming for years. Eg. Altria deal wasted tons of resources, time and killed the nicotine division. He should be banned from this company imho
CB was a failed CEO and could not commercialize ViPova tea, Protein bars or any of other CBD Products. The hybertension Phase2/3 is too not started and he jumped on GLP-1 drugs hype, once that is gone, he will jump on something else. IF the technology is that great, why not get license deal like others have got.
LEXX was unsuccessful with CBD because it wasn't clinically tested and approved for a particular medical affliction. The idea with the oral Liraglutide and/ or CBD for Hypertension is the drugs, after testing and approval, would be the only oral drugs of their kinds in the world and could be subscribed by doctors for whatever they are approved to treat. i.e. hypertension, weight loss, T2 diabetes amongst many other afflictions being discovered all the time! IMO It's definitely a good side bet for them.
https://lexariabioscience.com/2025/02/20/lexarias-strategic-business-pursuit-of-dehydratech-liraglutide/
Granted new mgmt...but I feel like you might be right. I would like to see it, but seems like an empty threat simply because they could have already had their own products (NSAIDs, ED drugs) if they really wanted to be a manufacturer/producer. If they were serious, and wanted to make products, they would have jumped at knocking off existing drugs when the FDA approved their tech as not altering the carrier drug. Plus, historically, ViPova tea, TurboCBD, Chrgd...not exactly successful products. Their primary goal is still licensing. Maybe the idea of a competing at a product level speeds up an offer?
The line about developing their own products -- not too sure about that https://lexariabioscience.com/2025/02/27/the-global-revolution-in-healthcare-driven-by-glp-1-drugs-and-the-role-of-lexaria-bioscience/
My guess is more dilution, high R&D expenses by Dr John for rat studies on multiple fronts ( good but big pharma is not. impressed by binders filled with various rat studies) and mgt salaries just for Bunka, Dr John and the new CEO at about a million a year plus perks. A miracle if I get my money back. IMHO GLTA
Can someone explain to me why this is dropping like a rock?
U:LEXX Lexaria's Strategic Business Pursuit of DehydraTECH-Liraglutide
Pursuing the world’s first-ever orally-dosed liraglutide
Kelowna, British Columbia – February 20, 2025 – TheNewswire - Lexaria Bioscience Corp. (Nasdaq: LEXX, LEXXW) (the “Company” or “Lexaria”), a global innovator in drug delivery platforms, announces that it has made a strategic business decision to further investigate the commercial opportunities and applications for a unique new GLP-1 solution: orally taken liraglutide processed with our wholly-owned DehydraTECH™ enhancement technology.
“Our ability to work with liraglutide, which went off-patent last year, is an opportunity that does not often present itself,” said Rich Christopher, CEO of Lexaria. “Lexaria has already demonstrated that our unique DehydraTECH technology seems to deliver potent oral delivery performance characteristics to liraglutide. This opens the door to the possibility of Lexaria developing and selling the world’s first oral capsule or tablet version of liraglutide.”
As part of that strategic business decision, Lexaria has already filed certain patent applications related to DehydraTECH-enhanced oral liraglutide which, if granted, will further support Lexaria’s ability to commercialize oral DehydraTECH-liraglutide. Presently, there is no oral version of liraglutide available commercially anywhere in the world and Lexaria is hopeful that potential new patent awards in this sector could be of strategic value to the Company.
Lexaria’s patent applications are reinforced by the successful animal study results announced on November 20, 2024 that evidenced superior pharmacodynamic (“PD”) performance. In that study, DehydraTECH-liraglutide outperformed the Rybelsus® control group by week 12 both in terms of blood sugar and body weight control, by 11.53% (p<0.0001) and 11.13% (p=0.0395) respectively.
Those positive study results reinforced Lexaria’s diversified strategy to conduct work, all at the same time, on all three of the world’s leading GLP-1/GIP weight-loss/diabetes drugs: liraglutide, semaglutide, and tirzepatide. Estimated global 2024 revenue of these three drugs is~$30 billion, compared to just $300 million in 2018, an increase of 100x or 10,000%.
To support the broader strategy of entering the GLP-1 weight loss and diabetes control market as quickly as possible, Lexaria is also preparing to commence pilot clinical testing of DehydraTECH-liraglutide in humans, as announced on January 15, 2025, when we received the necessary independent ethics board approval that allowed our contract research organization to begin to implement and execute human pilot study GLP-1-H25-5 (the “Study”). That Study will compare an oral version of liraglutide, formulated from the DehydraTECH-processing of Saxenda® to the conventional injected liraglutide (Saxenda®).
If that Study is successful, Lexaria intends to begin additional registrational clinical testing to demonstrate wider safety and PD performance utilizing orally-dosed DehydraTECH-liraglutide. Positive results could then be used as part of a potentially accelerated regulatory approval pathway with the Food and Drug Administration to seek approval to launch the world’s first orally-dosed liraglutide, ideally with the approval of liraglutide’s developer, Novo Nordisk®.
Liraglutide is currently sold only in an injectable form under the brand names Saxenda® and Victoza®, both manufactured by Novo Nordisk®. Despite the launch of a genericized injected version of liraglutide by Teva® during 2024, liraglutide sold by Novo Nordisk® under the brand names of Saxenda® still generated US$849 million in the first half of 2024; and generated an additional US$1.6 billion in recent annual revenue under the brand name Victoza®.
Approved for use by diabetics to control blood sugar, liraglutide has also evidenced an ability to slow cognitive decline and reduce shrinkage of those areas of the brain that control memory, learning, and language by nearly 50% as compared to placebo in a Phase 2b clinical trial.
About Lexaria Bioscience Corp. & DehydraTECH
DehydraTECH™ is Lexaria’s patented drug delivery formulation and processing platform technology which improves the way active pharmaceutical ingredients enter the bloodstream through oral delivery. Lexaria has developed and investigated DehydraTECH with a variety of beneficial molecules in oral formats. DehydraTECH has repeatedly demonstrated the ability to increase bio-absorption and has also evidenced an ability to deliver some drugs more effectively across the blood brain barrier. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 48 patents granted and additional patents pending worldwide. For more information, please visit www.lexariabioscience.com.
CAUTION REGARDING FORWARD-LOOKING STATEMENTS
This press release includes forward-looking statements. Statements as such term is defined under applicable securities laws. These statements may be identified by words such as "anticipate," "if," "believe," "plan," "estimate," "expect," "intend," "may," "could," "should," "will," and other similar expressions. Such forward-looking statements in this press release include, but are not limited to, statements by the company relating the Company’s ability to carry out research initiatives, receive regulatory approvals or grants or experience positive effects or results from any research or study. Such forward-looking statements are estimates reflecting the Company's best judgment based upon current information and involve a number of risks and uncertainties, and there can be no assurance that the Company will actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements. As such, you should not place undue reliance on these forward-looking statements. Factors which could cause actual results to differ materially from those estimated by the Company include, but are not limited to, government regulation and regulatory approvals, managing and maintaining growth, the effect of adverse publicity, litigation, competition, scientific discovery, the patent application and approval process, potential adverse effects arising from the testing or use of products utilizing the DehydraTECH technology, the Company’s ability to maintain existing collaborations and realize the benefits thereof, delays or cancellations of planned R&D that could occur related to pandemics or for other reasons, and other factors which may be identified from time to time in the Company's public announcements and periodic filings with the US Securities and Exchange Commission on EDGAR. The Company provides links to third-party websites only as a courtesy to readers and disclaims any responsibility for the thoroughness, accuracy or timeliness of information at third-party websites. There is no assurance that any of Lexaria’s postulated uses, benefits, or advantages for the patented and patent-pending technology will in fact be realized in any manner or in any part. No statement herein has been evaluated by the Food and Drug Administration (FDA). Lexaria-associated products are not intended to diagnose, treat, cure or prevent any disease. Any forward-looking statements contained in this release speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statements or links to third-party websites contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.
INVESTOR CONTACT:
George Jurcic - Head of Investor Relations
ir@lexariabioscience.com
The only way Teddy gets interviews is by writing what the MGT wants...
It is known every time this dick head releases his report, the price goes down by 10-15. Both the Chris have been using him to dilute
Why I think Lexaria Bioscience deserves a market cap many times higher…………………..…………p 7
https://4495825a-d729-4d8f-ade8-e78f828e1c8d.usrfiles.com/ugd/449582_35ed41ca581a44afa5feb3df3fe46379.pdf
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Lexaria Bioscience Corp. (CSE:LXX; OTCQX:LXRP) has developed and out-licenses its disruptive and cost-effective DehydraTECH™ technology that promotes healthier administration methods, lower overall dosing and higher effectiveness of ingestible drugs and other beneficial molecules.
Lexaria’s DehydraTECHTM delivery technology is protected by a robust suite of patents granted or pending worldwide and is proven effective in multiple international studies in greatly assisting rapidity and quantity of absorption of a range of lipophilic (i.e., fat-soluble), bioactive molecules. By significantly enhancing the performance and experience with oral ingestion, Lexaria’s DehydraTECH delivery technology offers a viable and often healthier alternative to other delivery methods for bioactive substances in widespread use today such as inhalational delivery through smoking.
Lexaria’s patented technology, DehydraTECH™ delivers these important benefits:
Eliminates the strong tastes/odors of lipophilic compounds, without the need for unwanted sugar or sweeteners
Effects are felt within 15-20 min vs. 60-120 min.
Initial testing indirectly evidences DehydraTECH may deliver ingested molecules through the lymphatic system instead of being subject to immediate “first pass” liver exposure, potentially mitigating unwanted side effects and reducing liver biotransformation.
Bio-absorption increases up to 3 – 10X, to equate or exceed that of other routes of administration like inhalational delivery.
Lexaria’s DehydraTECH™ is designed specifically for formulating and delivering lipophilic (i.e. fat-soluble) drug payloads. It is patented or patent-pending for use with a broad range of bioactive molecules, including but not limited to:
Lexaria Bioscience Corp. (“Lexaria”) has formed the Lexaria Nicotine Corp. as its exclusive worldwide nicotine business unit. More than 89% of all nicotine that is consumed worldwide is delivered through smoking cigarettes. Approximately 6,000,000 deaths per year around the world are attributed primarily to the delivery of nicotine through the act of smoking according to the Centers for Disease Control and Prevention. Of note: “…it is primarily the toxins and carcinogens in tobacco smoke – not the nicotine – that cause illness and death.” (U.K. National Institute for Health and Care Excellence [NICE]). As many as 69% of U.S. adult smokers want to quit smoking and 43% of US adult smokers have attempted to quit in any twelve-month period. Lexaria postulates that delivery of nicotine to satisfy current demand, utilizing our patented DehydraTECH technology in common food and consumer product formats, could shift demand away from smoking cigarettes. However, ingestion of nicotine is challenging because it is poorly tolerated by the human gastrointestinal system and then significantly metabolized by the liver, thereby diminishing its overall effectiveness through edibles. Lexaria’s DehydraTECH technology offers a means to formulate ingestible product formats of nicotine and/or its analogs with higher bioavailability performance possibilities due to the benefits of our technology.
Lexaria is developing a patent suite with supporting intellectual property in the pharmaceutical sector that will supply significant long-term strategic growth potential. Lexaria Pharmaceutical Corp. is the 100%-owned subsidiary that has obtained exclusive worldwide rights to Lexaria’s patent portfolio related to pharmaceutical applications. Currently within this business unit resides the IP for Non-Steroidal Anti-Inflammatories (NSAIDs), Vitamins, hormone treatments utilizing estrogen or testosterone, phosphodiesterase inhibitors (PDE5). Additional molecules of interest could be added to this unit over time.
According to Statista.com, the global pharma industry was worth $1,105 billion in 2016, and the US pharma industry alone spent over $71 billion in 2017 on R&D: a larger R&D expenditure than the entire gross revenues of many other business sectors.. Lexaria Pharmaceutical Corp. is implementing a strategy of reinforcing its IP-suite to sufficient degree to begin partnering within this dynamic industry.
The Lexaria Hemp Co. holds exclusive global rights to the Lexaria patent portfolio related to hemp-based applications. Lexaria’s DehydraTECH technology is designed to deliver functional ingredients within hemp in oral product formats with significantly enhanced palatability, speed of effectiveness and potency as a viable and healthier alternative to conventional inhalational (i.e. smoking or vaping) administration practices. Extensively evaluated through invivo, invitro, and human clinical studies, one of the most extensive databases in the world has been collected by Lexaria related to hemp-based ingredients empowered with our DehydraTECH technology. In 2018, the World Anti Doping Agency (WADA) for the first time ever exempted cannabidiol from hemp from its list of restricted substances on its International Standards Prohibited List of substances.
Lexaria CanPharm Corp, a Canadian corporation, owns exclusive global rights to Lexaria’s intellectual property as it is applied to psychotropic bioactive molecules that act upon human CB1 and CB2 receptors in those areas of the world where it is permissible to do so. Substances that act upon these receptors and systems in the human body that affect pain, inflammation, anxiety and depression, and have also been shown to have utility against cancer and neurodegenerative conditions. Lexaria’s ground-breaking 2018 research that proved many-fold improvements in delivering an active ingredient across the blood-brain-barrier could have disruptive potential within this business sector as well as all others where Lexaria is active.
The safety and effectiveness of Lexaria’s DehydraTECH™ technology has been studied in a series of controlled and well designed in vitro and in vivo human focus studies, examining factors such as total bioabsorption directly and indirectly through surrogate biomarkers, time to onset of effectiveness, flavor appeal and quality of effectiveness. Studies to-date have focused on cannabinoid applications where Lexaria is most advanced commercially, although research is underway for the other bioactive compounds named in Lexaria’s patent portfolio and described under Commercial Applications.
Pre-Clinical Research into Lexaria’s DehydraTECH™
An in vitro absorption study was performed to assess unidirectional CBD permeability using a human epi-intestinal tissue model with various formulations in the presence of simulated intestinal fluid. The study was designed to, as closely as possible, mimic intestinal absorption as it would occur in a live subject. Samples of Lexaria’s commercially available CBD-fortified ViPova™ black tea were administered in the model compared with concentration-matched CBD control preparations that lacked Lexaria’s patented formulation and process enhancements. The study showed as much as a 499% improvement, on average, in intestinal tissue permeability with the ViPova™ black tea formulation relative to a concentration-matched CBD control preparation without any Lexaria technology enhancements. The study also showed a 325% improvement, on average, in intestinal tissue permeability comparing the ViPova™ black tea preparation to a concentration-matched CBD control preparation that utilized Lexaria`s dehydration synthesis processing methodology but lacked its fatty acid ingredient incorporation, demonstrating the power of the Lexaria technology as a whole (see Figure 1).
Following this study, a series of independent, well designed, well controlled human focus studies were undertaken corroborating Lexaria’s in vitro performance findings. A study in healthy volunteers (n=6) suggested as much as a 5-10X increase in CBD absorption, which was assessed indirectly through measurement of the increase in salivary nitric oxide as a directly proportional surrogate biomarker, with onset of action in as little as 15-30 minutes. In all cases, the maximum increased level of salivary nitric oxide remained evident at the 60-minute end period of this particular test. Further testing is required to determine the full duration of elevated nitric oxide levels.
Thereafter, a blinded human focus study was conducted to evaluate the performance of THC-infused chocolates formulated using Lexaria’s DehydraTECH™ technology. This study compared the performance of the THC-infused chocolates powered by Lexaria’s technology to concentration matched THC-infused chocolates formulated using a commercial dextrin absorption enhancer. The subjects (n=12) that participated in this study indicated a clear preference on taste and overall effectiveness with the chocolates formulated using Lexaria’s technology, and onset of effectiveness was again observed very quickly, in as little as 15-20 minutes.
Lexaria Bioscience Corp’s disruptive new patented technology DehydraTECH™ is available to be licensed.
DehydraTECH can be used to improve existing products or to create new products. It is suitable for use with a wide range of consumer product formats including:
DehydraTECH is designed to be effective in delivering most fat-soluble molecules through the human gastrointestinal system and has also demonstrated affinity for transdermal applications and even effectiveness in crossing the blood-brain-barrier once within blood plasma. Lexaria has, or is conducting, in vitro, in vivo and human clinical testing, including pharmacokinetic data gathering, for the delivery of API’s through ingestible means. Test data has consistently pointed to reduced time required to enter the bloodstream, increased absorption rate, and reported improvements in taste and smell of edible products.
Contact us today to speak about your licensing needs at ablanchard@lexariabioscience.com
Terms and rights associated with our licensing opportunities are discussed on an individual basis.
Lexaria’s typical approach to working with a new prospective licensee is to effect confidentiality terms and then collaborate with the license prospect under a non-binding letter of intent to evaluate the feasibility and applicability of the Lexaria DehydraTECH technology for the license prospect`s needs. Following this, if the license prospect is satisfied with the performance enhancements delivered by the DehydraTECH technology, Lexaria then seeks to transition to a definitive fee bearing agreement structure between it and the new licensee.
We will license our technology in any of the more than 40 countries around the world where the DehydraTECH is patented or patent-pending. Licensees can feel confident that Lexaria’s extensive IP portfolio – constantly expanding – will help to provide a competitive edge and protection against inferior methodologies or older, outdated technology.
If your company works in a different but related field, please contact us if you’d like to conduct research on applicability for your specific application.
Licensees should also always remember that DehydraTECH costs less than a penny per serving to implement – sometimes a bare fraction of a penny. Licensees may experience an increase in market share or an increase in pricing power as a result of offering their customers superior delivery characteristics. Customers are loyal to the improved performance of DehydraTECH based products.
DehydraTECH is one of the world’s ONLY delivery technologies that does not require the addition of chemicals or intimidating, complex ingredients requiring disclosure on a food label. DehydraTECH works with commons GRAS ingredients that can be organic, gluten-free, and dairy free.
If your company works in a different but related field, please contact us if you’d like to conduct research on applicability for your specific application.
Masks taste/odor
Eliminates the strong tastes/odors of lipophilic compounds, without the need for unwanted sugar or sweeteners.
Reduces time of onset
Effects are felt within 15-20 min vs. 60-120 min.
Increases bio-absorption
Increases bio-absorption by 2 – 10x, to equate or exceed that of other routes of administration like inhalational delivery.
Avoids first-pass liver metabolism
Testing has evidenced that DehydraTECH may deliver molecules through the lymphatic system instead of being subject to immediate “first pass” liver exposure, potentially mitigating unwanted side effects. More recent testing in animals even demonstrated an ability to cross the blood-brain-barrier to a degree previously thought not possible.
Interview with CEO Chris Bunka
https://youtu.be/9bRSWYKIEL8
New Enhanced DehydraTECHTM formulation delivers 8X more CBD into blood and over 19X more CBD into brain tissue than standard industry formulations.
Kelowna, British Columbia – June 4, 2019 – Lexaria Bioscience Corp. (OTCQX: LXRP) (CSE: LXX) (the “Company” or “Lexaria”), a drug delivery platform innovator, has discovered improved performance characteristics of a new version of the DehydraTECHTM delivery platform initially suitable for use in solid oral dosage forms like capsules, tablets and pills for the pharmaceutical, medical, and supplement markets. Lexaria’s innovative use of a naturally sourced formulation enhancement more than doubles DehydraTECH’s absorption performance compared to previous DehydraTECH results demonstrated to-date. The Company has filed new patent applications related to the recent innovations.
BACKGROUND
On March 20, 2019 Lexaria announced it was beginning a series of animal studies with multiple objectives, including evaluating enhanced DehydraTECH formulations that might offer improved performance. Copious data streams have been generated from these tests and continue to be analyzed.
In this arm of animal study, Lexaria tested its DehydraTECH delivery technology with compounds postulated to behave in a synergistic fashion for enhancement of gastro-intestinal absorption, which resulted in significantly enhanced DehydraTECH performance (“Enhanced DehydraTECH”).
Of note, the new Enhanced DehydraTECH and its improved performance is separate and distinct from the nanotech improvement techniques recently announced by the Company.
TEST RESULTS
In each arm of the Lexaria animal studies, 10 male Sprague-Dawley rats were administered an identically sourced CBD at a rate of 25mg per kg of bodyweight. Delivery of CBD into the bloodstream was measured at 2; 4; 6; 8; 12; 15; 30; 45; and 60 minutes after dosing. DehydraTECH-enabled CBD was measurable in animal blood within 2 to 4 minutes after dosing.
On May 15, 2019 the Company reported that DehydraTECH achieved a CBD blood concentration level that was 475% more than a generic industry medium chain triglyceride (“MCT”) coconut-oil formulation 15 minutes after dosing. Today, the Company reports that Enhanced DehydraTECH led to 811% more CBD delivery into blood than generic industry MCT coconut-oil formulations (p=0.00008); and 110% more CBD into blood than DehydraTECH in its traditional format (p=0.02).
Also of note is that both traditional DehydraTECH and Enhanced DehyraTECH delivered maximum blood concentration levels prior to the 60-minute end-of-test, with levels tapering off thereafter. The DehydraTECH technology therefore demonstrates both fast onset and fast offset as tested which is of interest for dose titration purposes when repeated dosing is desired.
CONCLUSION
DehydraTECH’s in its traditional format has been used commercially by the Company since 2014; and by the Company’s technology licensees since 2016. Lexaria has consistently introduced leading innovation for oral cannabis formats such as capsules, beverages and edibles, with a focus on the consumer experience as measured by qualities such as taste, rapidity of onset and offset, and reliability of effect. Unique among the cannabis industry, DehydraTECH has proven itself equally transformative in other sectors such as the nicotine industry where Lexaria has licensed its technology to one of the largest nicotine products companies in the world.
Enhanced DehydraTECH seems particularly adept at delivering previously unreachable quantities of CBD across the blood brain barrier and into brain tissue; more so than even the most advanced nanotech as previously reported utilized in these studies. Since most human receptor cells of the CB1 variety and otherwise that are associated with the psychotropic effects of cannabinoids are located within the brain these findings significantly expand upon the power of Lexaria’s technology to reach the target site of action for these purposes.
With this new innovation, Lexaria is establishing new performance thresholds for drug delivery technology, with tested performance of 8x (blood plasma) and more than 19x (brain tissue) of generic industry formulations. The Company intends to perform further studies to fully characterize Enhanced DehydraTECH and will work throughout 2019 to optimize implementation into the best product applications for use by its licensees.
The animal test results announced to date have led to additional new patent applications based on the positive performance results achieved. The specific nature of enhanced DehydraTECH shall remain undisclosed for proprietary reasons until the new patent filings are published. Although the current tests were limited to CBD absorption, Lexaria expects knowledge from the current innovation to apply equally to tetrahydrocannabinol (THC) as well to enhance formulation innovation for nicotine and various pharmaceutical compounds already named within the Lexaria patent suite.
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