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Re: falconer66a post# 356518

Wednesday, 04/06/2022 10:00:44 AM

Wednesday, April 06, 2022 10:00:44 AM

Post# of 462345
AVXL IS NOW THE WORLD CARDIOLOGY LEADER DESPITE ONLY RUNNING A 17 PATIENT P1 STUDY IN HEALTHY PATIENTS!!!!!!!!!!

Ok, blarcamesine (Anavex 2-73) and its metabolite, Anavex 19-144, fixes heart beat rhythm anomalies. Anavex now has cardiac disease therapies




Seventeen subjects contributed ECG data to the analysis dataset. The study was randomized single dose escalating phase I first-in-human study designed to investigate the safety and tolerability, and pharmacokinetics of ascending oral doses of ANAVEX 2-73 in male healthy subjects. It was double-blind and placebo-controlled within each dosage step--a two cohort study with alternating single dose escalation performed in male healthy subjects. Subjects were administered 10, 30, 40, 50, or 60 mg of ANAVEX 2-73 orally with a 4-week washout between doses. Sampling for drug and ECG was from predose to 48 hr.



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