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Re: plexrec post# 355025

Tuesday, 03/22/2022 1:49:50 PM

Tuesday, March 22, 2022 1:49:50 PM

Post# of 462347
Plexrec, is this holding up our PdPdd trials?
MJF Foundation article is trumpeting their support for the development of this imaging tracer (quote) "because of its potential to transform drug development."

And another similar quote from the article about developing Parkinsons drugs:

Misfolding and clumping of the alpha-synuclein protein in brain and body cells are the pathological hallmark of Parkinson’s disease. Scientists believe this toxic dysfunction gives rise to Parkinson’s onset and progression. The ability to visualize alpha-synuclein activity in the living brain would be a game-changer for testing and developing potential new Parkinson’s drugs.



It really sounds like MJFF is 100% behind this imaging technology for drug development.

Did our partner MJFF tell Dr.M, please wait, we want to include imaging in the next Anavex PD trials to track the disease. The imaging will be ready SOON (now?).

I hope this is incorrect, otherwise it would seem that efficacy, patient improvement and revenue are not as important as the exact determination of the MOA! But it makes me wonder. If our partner MJFF did say this to Dr.M, I think Dr.M would not be happy about the situation. And perhaps why he recently said he did not want to talk about the PD/PDD trials.

Plex, interesting article, thanks for posting. BTW does the "Misfolding and clumping" sound familiar?


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