Aurinia Pharmaceuticals Inc (AUPH)

[Whalatane]

BR all credit goes to you for being the first that I'm aware of ...of alerting this board to the potential re KZR .
As to why the new high
My guess its a run up to the P2 data due to be released in mid / late Q2 ...on 2 trials actually ...PRESIDIO and MISSION .
What most will be looking at re MISSION for LN is safety and what % can achieve proteinuria levels below .05 ...without the additional need for steroids
While those on Lupkynis are able to taper their steroid use ...only those on KZR 616 have been able to go completely off steroids within 12 wks and still maintain targeted proteinuria levels ( proteinuria levels being one of the best indicators of risk to kidney function )

So why is steroid use such a big deal ?
Because the patients ( mostly young women ) hate them .
They make them look ...in their words ...4 months pregnant , prone to mood swings and prone to infections .
This is the reason why its so hard to keep these patients on ANY LN therapy that requires use of steroids .

IF KZR 616 can get proteinuria levels to goal and maintain it there with a high safety profile without the need for steroids .....it will , according to HC Wainwright , have the potential to be ..

.a disruptive new therapeutic approach

We'll know late Q2 2022

Kiwi