Anavex Life Sciences Corp (AVXL)

[falconer66a]

Thanks. Yes, this may require mouse studies.

Isn't the Sigma1 receptor a mammalian mechanism?

Thank you for this important question.

To answer it I had to search around; found no definitive answer, only that one source said it is a "mammalian protein." It therefore may not be found in other taxa. It very likely is absent in invertebrates. Certainly, if it's not in nematodes, they can't be used to test blarcamesine as an anti-aging agent.

Instead, mice will have to be used. Mice do have sigma-1 receptor proteins, which function as they do in humans. So, instead of a few weeks of exposure, in mice it will take many months or a few years to detect anti-aging outcomes.

Perhaps Missling has someone testing blarcamesine in mice. There are mouse strains with an extended or a shortened life span as models of aging.

"...in the field of aging, mice have become very robust and reliable research tools. Since laboratory mice have a life expectancy of only a few years, genetic approaches and other strategies for intervening in aging can be tested by examining their effects on life span and aging parameters during the relatively short period...."

https://pubmed.ncbi.nlm.nih.gov/22543101/

Or, later, the anti-aging functions of blarcamesine will be discovered in long-term studies of humans taking the drug as a CNS disease therapy. Results wouldn't appear for at least a decade, after it's quantified that people on the drug simply live longer than those not on it.