Anavex Life Sciences Corp (AVXL)

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Glaucoma Will Be Just One of Many

Sigma 1 Receptor Protein Protects Brain Cells Most Impacted by Glaucoma

Of course, this was a serious technical paper in a peer-reviewed medical journal. It showed that when sigma-1 receptor functions are compromised or disturbed, in this case by glaucoma, brain cell functions are pathologically impaired. No mention of blarcamesine as a therapy, but pathological involvement by compromised sigma-1 receptors was clearly shown.

Clearly very important for cases of glaucoma. Very good chance that blarcamesine could obviate the brain cell dysfunctions caused by glaucoma.

But this is just another new finding about the sigma-1 receptor protein, when it functions properly; something that blarcamesine facilitates. The involvement of the sigma-1 receptor protein continues to be discovered in ever greater numbers of diverse pathologies. Because of proper activation of the protein by blarcamesine, any number of additional, unexpected pathologies may favorably yield to blarcamesine therapies.

Five or six years ago there were daily postings on this message board claiming that blarcamesine’s (Anavex 2-73's) “activation” of the then little-known sigma-1 receptor protein was highly questionable. The molecule apparently did bind to the sigma-1 receptor protein, but so what? Sigma-1 receptor biology was poorly and incompletely known. How this protein might be able to modulate or facilitate a diverse number of otherwise unrelated cell processes was unknown; therefore it was disregarded. Impossible, it was contended.

Notice that such naysaying postings haven’t recently appeared. Sigma-1 receptor biology is becoming known and understood. Do a PubMed search on “sigma-1 receptor protein” and see what comes up. A multitude of new papers in the last several years. It’s newly-discovered cellular biology, with profound applications. This new paper on sigma-1 and glaucoma is an example of the many others that will be published soon enough. The evidence continues to accumulate: compromised function of the sigma-1 receptor protein causes an ever-widening spectrum of diverse pathologies. Eventually, it will be discovered that restoration (or maintenance) of sigma-1 receptor functions by blarcamesine will yield profound health benefits, for a diversity of seemingly unrelated diseases. In the twentieth century it was antibiotics that yielded the greatest therapeutic results and changed medical practice. In this century it will be blarcamesine.