NorthWest Biotherapeutics Inc (NWBO)

[Chiugray]

Thanks Flipper. Complex. I had to read thru several times to digest. Basically single agent treatment results in an adapting ecosystem can be optimized.

Formula: DCVax-l + CI + CSF1R (odd-3397) + poly ICLC.

- DCVax dendritic cells is the activation signal to get peripheral T-cells and B-cells to go into and kill tumor cells
- CI checkpoint inhibitors fight against the tumor’s defense mechanism of turning off the T-cells ability to see cancer cells (tumor sends PD-L1 to bind on the attacking T-cells)
- CSF1R (odd-3397) is the inhibitor that reduces CSF1R so there is less suppressing of the immune system and lowering of macrophage levels
- Poly ICLC is the chemical that induces inflammation, so the immune system goes there, and as such the total response is enhanced