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Re: pcguy post# 351916

Saturday, 02/19/2022 3:02:39 PM

Saturday, February 19, 2022 3:02:39 PM

Post# of 463510
Probably oversimplified.

Trial size calculations are just a statistics problem.


Maybe closer to truth for a P3 trial where enough responder data is available to assess effect size before designing a P3 trial.

Without a good sense for effect size, then the trend would be towards a larger trial not to flunk a first attempt.

Anavex clearly must have felt they knew enough about expected effect size to go for the smaller trials.
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