Anavex Life Sciences Corp (AVXL)

[pcguy]

I should have known better, thanks Boi. Just because the trial size is different between companies does not mean it is less meaningful. Trials are powered to look for effect in different things, the drugs are not the same, thus the trials are not the same. As long as there is a significant corellation to the target population, an effect can be seen. Often trials are designed to be larger when the company has less confidence in reaching endpoints. This allows them to look for other effects in subsets of the trial population. A dirty precision medicine approach, ie. we don't know what else we may see, so cast a large net and look for any relationships. This happened in one of the AD trials from another company, can't remember off the top of my head. They ran the trial and after failure realized that a small subset of the population saw a larger decrease in AB plaque, so they re-ran the trial powered for the chacteristics of that subset. Larger poorly designed trials can lead to failure if you don't have bottomless pockets. There is nothing wrong with Anavex trial size, unless they change at the end of the trial, or attempt a very small trial population.