Marker Therapeutics Inc (MRKR)

[Phantom Lord]

Is THAT the "medicine/treatment" that was given to the one MRD positive patient and five frank relapse patients in the safety lead-in stage of the Marker Phase 2 AML trial?

No. This was one of the first people dosed in the safety lead in.

Did they delay the adjuvant group because they want to use the new "9 day, 4 times more potent" medicine/treatment in further adjuvant procedures?

Yes. It does seem that way.

And also, if the 5 frank relapse patients, the way I read it, were "frank" when they were given to us, as in they had ALREADY relapsed BEFORE MT-401 who knows how many times and from who knows how many different drugs and treatments, and therefore (I assume) must have been sick for a long time ... in other words, weren't the chances for "curing" very sick, already relapsed patients very small to start with?

This is what I have been saying FOREVER. The patients they are treating have already failed multiple lines of treatment. I think in the PI it was 4-10 prior lines of therapy failed. The active patients are running out of options and nothing is working. The chance of curing them is small. That is why they need to compare the therapy to DLI in the active group. If you do that then it's an efficacy match, or better, and WAY better safety profile. We just aren't going to see a ton of CRs in the active group.

How many already relapsed frank patients have others "cured"?

Good question. Probably not many.