Anavex Life Sciences Corp (AVXL)

[end2war]

ImGettingBetter and Investor

But I think Missling was trying to compare RSBQ Total Score versus RSBQ AUC. Missling stated that RSBQ AUC is a higher bar than RSBQ. RSBQ AUC is way to show that the drug is actually helping the patient. RSBQ can show an improvement, but may not really be helping the patient.

Missling's example - a patient has psoriasis covering the arm. The drug is provided to the patient. Under RSBQ the patient could show an improve such as 20% (as and example) which might be consider to some as significantly improved. In other words the patients coverage of psoriasis on the arm improved 20%. But the patient still has 80% psoriasis on the arm.

Under RSBQ AUC, that 20% improvement may show as a significant signal in a trial but you are not really helping the patient. So the 20% would not cut it as success. Missling went on to explain in his psoriasis example; under RSBQ AUC, the patient would have to show 75% removal of the psoriasis to count this as a responder. So he the latter part of the example relates to RSBQ AUC. A much higher bar.

I think ImGettingBetter hasa big part of it figured out here, but not the who enchilada! I just realized from how Investor explained it, combined with how you explained it, that apparently you have to combine both the AUC computation and the Anchoring to understand the part about why it is a higher bar or higher threshold.

This is what I think Missling is doing with the Anchoring:

Regardless of a patient's RSBQ score, they only counted a patient as a responder IF the Physician CGI-I score was 1-3. That is the threshold requirement. Then, and only then, do you count the RSBQ score as a responder. All other RSBQ scores that are positive go into the placebo category!!! That is why the Placebo category is crazy high at 39%. A bunch of those placebos were scoring well as responders on the RSBQ test alone. But with the anchoring, the RSBG score is rejected unless that patient got a CGI-1 score of 1-3.

Is that why it is more difficult to get Responders, AND also why there were so many placebo responders?

Anyone else have any thoughts? Please correct me if you think I am off.