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Tuesday, February 08, 2022 5:04:18 PM
"I think it's fair to say that we were not expecting such strong cognitive signals to emerge from a small n study that was not designed to capture statistical significance within the resultant cognitive dataset. To me it is very significant that all those who completed Part A elected to enrol in the 26 week extension, and as the first few patients began to return to the study sites for Part B visits we received the message from patients and carers that they wanted to continue on the study drug for longer, which prompted me to approach the sponsor to extend the study for a further 26 weeks.
To me, it was extremely encouraging to see any sign of a cognitive signal in a five-week study, and the strength of these signals was remarkable. I've been running Alzheimer's trials for over 16 years, and have never seen such a strong cognitive signal in any of the trials I've been involved in (including solanezumab). We've collected a number of verbatim quotes from study participants and their carers, which I'd be happy to provide to you in a deidentified form upon request."
Although dated from 11/15/2015, it still stands out as a great testimonial from one of the most respected doctors in the neurological science field.
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