Sunday, February 06, 2022 3:02:22 PM
Same thing with me. My father, with diagnosed Alzheimer’s was in the donepezil clinical trial. For a while, for some number of months, the drug seemed to slow the progression of symptoms. Then, an even stronger resumption of symptomatic progress, to death. My mother, an accomplished geriatrics nurse with much professional experience with Alzheimer’s said that had she had to pay for donepezil she would have not allowed it for my dad. The expense not worth the meager treatment benefits. He got the drug only because he was in the clinical trial.
Of course, presently, donepezil (trade name Aricept) is the SOC (standard of care) Alzheimer’s drug. It doesn’t work very well, or very long; but it’s all that’s available. In its big Alzheimer’s trial blarcamesine will have to demonstrate equal or greater treatment efficacies to get FDA approval. That won’t be hard. Aricept is a low hurdle to leap; easy to do for blarcamesine. No leap, just a small step is required. Blarcamesine Alzheimer’s results will be safe pole vaults over Aricept.
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