Anavex Life Sciences Corp (AVXL)

[TempePhil]

Highlights from Parkinsons Research Article - Dr.Simon Stott

I read Dr.Simon Stott's, rather long, but thorough article, "THE ROAD AHEAD: 2022". He broke down all of the research going on in the field of Parkinsons disease, with highlights of events to look for in 2022.

What stood out to me, was that he had the most praise for Anavex 2-73, with phrases like "This is rather jaw dropping stuff.". I was looking to see if he had kind words, like those, for any other treatment, but I did not see any. For others, I recall words like "very promising", and "looking forward to results". Dr.Stott's name should be added to our list with Dr.Hagerman et al.

The companies that seemed to have the best promise, were generally supported by MJF Foundation, or the "Cure Parkinsons Org", so kudos to them on supporting wisely. Simon openly pointed out the supported research.

Much of the research was in the preclinical, or phase1 stage, far fewer in Phase2, and even less in the Phase3 stage. This is to be expected, but what stood out to me was the depth and breadth of the research.

Also, of note were how failure was handled by a couple of companies (quoted):

Unfortunately, in February 2021, Biogen announced to their investors – in a single sentence buried deep in their annual results (PDF) – that the company had halted development of cinpanemab after the SPARK study missed its primary and secondary endpoints.

But then in February 2021, Sanofi announced in a single sentence of their annual report that “the venglustat Phase 2 trial in Parkinson’s with GBA mutations did not meet the primary endpoint (end-January) & the indication was halted”

The article was impressive for the outline Stott presented for categorizing the research/treatment approaches, the good explanations of the science, and the thoroughness of accurately presenting the status of so many companies and treatments. A very solid starting point for anyone researching the status of Parkinsons research, or the players in the game. A fascinating, thorough and educational read, but of necessity...long. (However, if you read it in one sitting, Dr.Stott promises to buy you a beer.NICE! UK has great beers!)

Dr.Stott has a PHD in Neurobiology and has been a researcher in the John van Geest Centre for Brain Repair. He is Deputy Director of Research at The Cure Parkinson's Trust. He maintains a blog at WORDPRESS.COM

Sorry I did not take notes as I read. These are just points that stuck out to me.

Thanks TTT for another good contribution! For the link to the article, see TTTav66 post # 347193.