Anavex Life Sciences Corp (AVXL): The predictive biomarker of response est...

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georgejjl

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Thursday, 01/27/2022 9:53:50 PM

Thursday, January 27, 2022 9:53:50 PM

The predictive biomarker of response established with SIGMAR1 mRNA expression,” Christopher U. Missling, PhD, president and chief executive officer, Anavex, said in a statement.1 "We believe that the easily accessible predictive biomarker combined with the observed efficacy is a consistent explanation of the efficacy in this second largest CNS indication with unmet medical need. This data further strengthens the foundation of ANAVEX 2-73 as a cross-platform (central nervous system) drug.”

https://www.neurologylive.com/view/blarcamesine-increases-sigmar1-expression-improvements-parkinson-dementia

ANAVEX®2-73 Establishes SIGMAR1 mRNA Predictive Biomarker of
Efficacy in Alzheimer’s, Parkinson’s and Rett Syndrome

Biomarkers of response and/or surrogate endpoints: Genomic biomarker: DNA & mRNA profiles; Glutamate, GABA

Glutamate biomarker

https://www.anavex.com/_files/ugd/79bcf7_3dc7aeae98c145f8b80acfa95798dad1.pdf

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