NorthWest Biotherapeutics Inc (NWBO)

[AVII77]

A doctor that prescribes (for many years on end) an expensive toxic therapy he readily admits doesn’t work in unmethylated patients is a sadist, particularly when he knows it also reduces the immune system’s limited capacity to fight the tumor in unmethylated patients.

So, that would include every single medical oncologist in the world who treated a nGBM patient since 2006.

EVERYONE uses temodar in nGBM; both for methylated and unmethylated cases.

You are saying Dr. Liau is a sadist then? Very interesting. She routinely gives temodar to nGBM patients, both MGMT+ and -.

No. You are clearly not understanding the science and the literature.

Temodar's benefit is small in MGMT-. But only a sadist would deny it to a patient (outside the setting of a clinical trial. and it would be a challenge to get the FDA and IRB's to approve such a trial).

Stupp was advocating for trials seeking treatments for these MGMT- patients (and argued since the benefit, though real, was so small, if they used an appropriate cut-off for MGMT it would be ethical, assuming informed consent was given of course, to not use temodar in the experimental arm).

Before some IHUB-message-board-educated poster accuses a noted physician of being a sadist, they should at least try to understand the clinical landscape.