Anavex Life Sciences Corp (AVXL)

[falconer66a]

Full potentials not yet recognized or discovered.

One day, you will be amazed how everything has changed...

For Anavex naysayers, for those who wish not to consider or contemplate any drug or molecule not approved by the FDA and in full therapeutic operation, read no further. All of this is way too far out. All speculation and conjecture. Not worth your time even reading. Has absolutely no application in regard to the purchase or sale any AVXLs.

I, too, was amazed at today’s inclusion of schizophrenia as a new Anavex target disease, now with Anavex 3-71. Applying 3-71 against Alzheimer’s made sense. Blarcamesine and Anavex 3-71 have analogous mechanisms of reaction, MOAs, where they propitiously bind to the sigma-1 receptor protein and thereby activate it, allowing it to modulate and facilitate a diversity of downstream reaction cascades and processes.

But schizophrenia? Ostensibly, that’s a much different CNS disease. It may exist, but I haven’t seen any previous studies or information linking schizophrenia to sigma-1 receptor dysfunction. But Anavex will now test 3-71 against this otherwise rather recalcitrant psychosis. They know something.

I and others have already laid out how blarcamesine is likely to prove to be a very powerful prophylactic, preventing a wide diversity of CNS diseases and conditions of geriatric incidence; an anti-aging drug, if you will.

I’ve also conjectured that because of the drug’s favorable modulation of chromatin biology, allowing full and proper expression of the genes in DNA otherwise enclosed in chromatin in chromosomes, it might prove successful preventing the onset of any number of genetic anomalies; even, perhaps, prompting the suppression of mutant genes in gametogenesis, the production of ova and sperm, thereby obviating birth defects.

It is becoming ever more clear that endogenous (by agents outside of the cell) activation of the sigma-1 receptor protein (and muscarinic receptors, etc.) by the Anavex molecules, just a host of good things happen. The restoration or induction of proper autophagy clears toxins and wastes. The facilitation of proper protein folding allows production of fully functioning enzymes (which consequently control virtually all chemical reactions in the cell), and so forth.

In a previous posting I asked that we all check back in five years (when Anavex will be a major, global pharmaceutical). But, before that, I contend that it will be discovered that the Anavex molecules will be prophylactic and therapeutic for a broad expanse of human debilities. Moreover, it will be discovered that prophylactic applications will both prevent the onset of geriatric diseases and significantly slow aging processes in general.

Perhaps that’s what Methuselah and his cohorts were consuming; some now-vanished herb that produced micrograms of Anavex 3-71.

Lastly, Missling’s tangential reference, lo those several years ago, to the “Iceberg” effect rings ever more loudly. All of us in biology are aware of the use of Caenorhabditis elegans, a small, easy to culture and experiment with lab roundworm, to test anti-aging compounds. Dose the worms and see how much faster or slower they age. Can do that in a few weeks, not months or years. Anavex has surely dosed some C. elegans worms with their molecules, to see what happens.

Missling and the Anavex principals aren’t revealing all that they know about their drugs. But today, a bit more about Anavex 3-71 can be surmised. Schizophrenia, of all things. In the months and years to come, what else?