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IkeEsq

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IkeEsq

Re: Long and gone post# 430733

Thursday, 12/30/2021 10:26:04 AM

Thursday, December 30, 2021 10:26:04 AM

Post# of 693122

Could you explain what crossover is and why that would be a problem



In the Phase III trial, patients in the control arm who got the placebo could 'cross over' to the treatment arm and get DC-Vax if their tumors reoccurred (progressed). In the end, 90% of patients received DC-Vax. That makes comparison between the Treatment arm and Control arm more complicated as there are now three groups and a much smaller number of patients only getting the placebo.
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