NorthWest Biotherapeutics Inc (NWBO)

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Ten fold manufacturing increase is a meaningful difference.

As Senti pointed out, there are likely to be around a quarter of a million nGBM cases annually (globally).

Let’s pretend 100,000 of those cases would initially be eligible for dcvax.

What is the monthly manufacturing capability needed to meet the demand?

Answer, 8,300 per month.

How do you get from 50 per month to 8,300?

First determine how many at Sawston/Advent could be produced per month with Flaskworks and nearly full use of the entire facility. 50 * 10 * 8

Answer: 4000 per month.

How many more global hubs the size of Sawston/Advent would be required to meet an above initial annual demand of 100,000?

Answer: 1

After Flaskworks is approved, what type of facilities/hubs are needed.

Answer: GMP. However, multiple clean room suites are not required.

How large was Cognate/CRL in Memphis as of August 2020?

Answer: Approximately same size Advent/Sawston will expand to. 88,000 square feet.